Is the predictive power of previous fractures for new spine and non-spine fractures associated with biochemical evidence of altered bone remodelling? The EPOS study

Background: In the European Prospective Osteoporosis Study (EPOS), a past spine fracture increased risk of an incident fracture 3.6–12-fold even after adjusting for BMD. We examined the possibility that biochemical marker levels were 0009-8981/02/$ see front matter D 2002 Elsevier Science B.V. All rights reserved. PII: S0009 -8981 (02 )00164 -X * Corresponding author. Department of Medicine (Box 157), Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, England, UK. Tel.: +44-1223-741617; fax: +44-1223-741618. E-mail address: [email protected] (J. Reeve). www.elsevier.com/locate/clinchim Clinica Chimica Acta 322 (2002) 121–132 associated with this unexplained BMD-independent element of fracture risk. Methods: Each of 182 cases in EPOS of spine or non-spine fracture that occurred in 3.8 years of follow-up was matched by age, sex and study centre with two randomly assigned never-fractured controls and one case of past fracture. Analytes measured blind were: osteocalcin, bone-specific alkaline phosphatase, total alkaline phosphatase, serum creatinine, calcium, phosphate and albumin, together with the collagen cross-links degradation products serum CTS and urine CTX. Most subjects also had bone density measured by DXA. Results: Cases who had recent fractures did not differ in marker levels from cases who had their last fracture more than 3 years previously. No statistically significant effect of recent fracture was found for any marker except osteocalcin, which was 17.6% lower in recent peripheral cases compared to unfractured controls ( p < 0.05) and this was independent of BMD. Conclusion: Past fracture as a risk indicator for future fracture is not strongly mediated through increased bone turnover. D 2002 Elsevier Science B.V. All rights reserved.